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GUSTAVE ROUSSY
THÈME DU DIAPORAMA
Tanderup adiother Oncol 2016;120:441–46
Demonstration of clinical evidence for dose effect for CTVHR
3-year local control rates D90 CTVHR dose ≥85 Gy in 7 weeks:
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>94% in limited size CTVHR (20 cm3 )
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>93% in intermediate size CTV HR (30 cm3 )
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>86% in large size CTVHR (70 cm3 )
Doses of 90–95 Gy add 1–4% to local control
An increase of OTT by one week is equivalent to de-escalating
CTVHR dose by 5 Gy
An increased CTVHR volume by 10 cm3 requires an additional
5 Gy for equivalent local control.