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Bas
elin
e
Wk
1
2
3 4
5
Vol of
FBM
(cc)
V10Gy
(<90% -Mell
et al)
V40Gy
(< 40% -
RTOG 0418)
Mean Dose
FBM
(<25Gy)
Pt 1 0 0 0 0 0 Gr 1
425
74.2 % 25.6 % 24.9 Gy
Pt 2 0 0 0 0 0 Gr 1
482
83.9 % 34.9 % 29.0 Gy
Pt 3 0 0 0 Gr
1
Gr 1
Gr 2
446
79.7 % 35.9 % 27.5 Gy
Pt 4 0 0 0 Gr
1
Gr 1
Gr 2
702
69.3 % 13.2 % 21.9 Gy
Pt 5 0 0 0 0 0 Gr 1
409
83.1 % 18.3 % 24.4 Gy
Pt 6
0 0
Gr 4
*
Gr
2
0 0
272 95.3 % 28.9 % 28.8 Gy
TMH Experience : 9 pts recruited in phase II study
•
Baseline Active BM reserves were low
•
Dose constraints not achieved
•
Grade 4 HT toxicity