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Meta-analysis of 12 trials
with 1,800 patients with resectable gastric or gastroesophageal
cancer:
neoadjuvant chemotherapy
could significantly
downstage tumors
and
improve
R0 resection
while
slightly improving the overall survival
(
Xiong et al., Eur J Surg
Oncol, 2014
)
Additional meta-analysis
comparing neoadjuvant chemotherapy with surgery alone:
the
only significant finding
is that there were
significantly fewer negative lymph
nodes after neoadjuvant treatment
(
Xu et al., PLoS One, 2014
)
Neoadjuvant chemotherapy does not improve OS
03/27/2017