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3 preoperative and 3 postoperative cycles of
ECF
Primary endpoint:
OS
2-3 preoperative cycles and 3-4 cycles of postoperative
CF
Primary endpoint:
OS
The perioperative-chemotherapy group
had a
higher likelihood of overall survival
(hazard
ratio for death, 0.75; 95 percent
confidence interval, 0.60 to 0.93; P = 0.009;
five-year
survival rate, 36% vs 23%
)
The CS group had a better OS (
5-year rate 38% vs 24%
;
hazard ratio [HR] for death: 0.69; 95% CI, 0.50 to 0.95;
P
<0.02)
03/27/2017