Background Image
Table of Contents Table of Contents
Previous Page  88 / 116 Next Page
Information
Show Menu
Previous Page 88 / 116 Next Page
Page Background

PDE5-003

Cons/Weaknesses

Low throughput, only applicable to the analytes that can

be ionized at the condition used. In this case, only ESI

positive mode was used.

Supporting Data

General Comments

There are details in this work about the QC, data analysis,

and how to use the method with other techniques such

as NMR to fully characterize other unknowns etc. The

figures and tables are clear. There are some

inconsistencies with the parameters in the method

description and in the appendix, such as mass spectral

acquisition parameters.

Method Optimization

The method optimization is not specifically discussed;

however,the method description indicated that

optimization was performed based on the recommended

solvent selection for the extraction of the analytes and

also the recommend fragmentation parameters etc. of

mass spectrometer.

Performance Characteristics

Analytical Range:

1ug to 5 ug/mL.

LOQ:

Not applicable as a qualitative method

Accuracy/Recovery

Not applicable as a qualitative method

Precision (RSDr)

Not applicable as a qualitative method

Reproducibility (RSDR)

Not applicable as a qualitative method

System Suitability

It is not specifically discussed. Running standards before

running the samples will fulfil part of this requirement.

Safety Review

Is the method safe to use as written?

Yes

Are there any safety concerns with

any component, instrument, reagent

or instruction of the method? If yes,

please clearly state the concerns.

No extra safety concern is identified.

Does the method include all

necessary safety precautions and/or

warning statements? Yes or No. If

No, please suggest potential

precautions or warnings that can be

added to the method for users or

recommend safer option(s) if

yes