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Unrestricted
in vivo
diffusion
low cellularity & defective membranes
Restricted
in vivo
diffusion
high cellularity & intact membranes
What do we probe with Diffusion MRI?
Koh et al., AJR, 2007
Free diffusion
true Brownian motion
D
pure water
= 3 μm
2
/ms @ 37
°
D
in-vivo
≈ 1 μm
2
/ms @ 37
°
(depending on restrictions)
D(t)
=
−
0
2
2