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EMBRACE trial (1)

intErnational study on Mri-guided BRachytherapy in locally

Advanced CErvical cancer.

European study on MRI-guided brachytherapy in locally advanced

cervical cancer (GEC-ESTRO) started in 2008.

Accrual ended in December 2015, with > 1400 patients included.

Prospective observational multicenter setting

Primary endpoints: LC and morbidity.

Secondary endpoints: RC, DFS, OS and QoL.

Correlation between image-based DVH and outcome.

FIGO IB to IVA

EBRT + BT