Epidermal growth factor receptor (EGFR)
transcription
M
G1
G2
S
cell cycle progression
S
DS
S D
D
S
SS
SS
S
S
S
D
D
D
S
S
S
S
D
D
D
D
D
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
proliferation
angiogenesis
EGFR
growth factor
inhibition of apoptosis
S
SS
SS
S
S
S
D
D
D
S
S
S
S
S
metastases
cell membrane