1432 / 1983
Study
No.
study-
arms
No.
patients
No.
centers
Duration
(years)
Fu, Int J Rad Oncol Biol Phys 2000
fractionation
4
1113
45
6
Overgaard, Lancet 2003
fractionation
2
1476
6
8
Forastiere, N Engl J Med 2003
radiotherapy
±
chemotherapy
3
547 > 100
8
Bernier, N Engl J Med 2004
surgery+ radiotherapy
±
chemotherapy
2
334
23
7
Cooper, N Engl J Med 2004
surgery+ radiotherapy
±
chemotherapy
2
459 > 100
5
Bonner, N Engl J Med 2006
radiotherapy
±
cetuximab
2
424
73
3
Most influencial studies H&N cancer 2000-2006
3,1
15,4
< 0,5
1,0
< 0,5
0,9
No. patients in
experimental
arm per center
per year