1474 / 1983
BRCA
gene products are involved in:
Double-strand break repair
mechanisms
Cell-cycle checkpoints control
Regulation of apoptosis
"Caretakers" genes
Involved in the maintenance of
genome integrity and stability
Protein partners of BRCA1 in DNA damage responses. There is accumulating
evidence that BRCA1 performs multiple functions in the cellular response to
DNA damage through its interactions with different protein partners. The list of
BRCA1-interacting proteins indicated here is not exhaustive but illustrates points
made in the text (
Image Permit Pending
Venkitaraman,2001).