1477 / 1983
Family history: the highest breast cancer risk factor
Relative risk according to the number of affected first degree
relatives
Oxford meta-analysis
52 studies – 58 209 cases; 101 986 controls
Nb of affected first degree relatives Relative risk
None (reference)
1.00
One affected
1.80 (CI: 1.70 – 1.91)
Two affected
2.93 (CI: 2.37 – 3.63)
Three affected
3.90 (CI: 2.03 – 7.49)
Lancet, 358: 1389, 2000