1485 / 1983
Loco-Regional Therapy in
BRCA 1/2
Carriers
Collaborative Series
• Analysis of 655 women with
BRCA 1/2
– associated
invasive breast cancer treated with BCT or Mastectomy (M)
• All patients had Stage I – III breast cancer
• 302 patients treated with BCS + RT; 353 with M (103 with
RT; 241 without RT; 9 unknown)
• Median F/U
– 8.2 years BCT
– 8.9 years M
Pierce et al. BCRT, 2010