1530 / 1983
BRCA1
and
BRCA2
Tumors Characteristics:
Genome
Tirkkonen et al, Cancer Research, 1997
Van Beers et al, Cancer Research, 2005
Jönsson et al, Cancer Research 2005
Stefansson et al, BCR, 2009
Waddell et al, BCRT, 2009
Manie, Stern, unpublished data
20%
20%
100%
Frequency
1
2 3 4 5 6 7 8 9 10 11 12 13141516 17 1819202122
20%
20%
100%
Frequency
1
2 3 4 5 6 7 8 9 10 11 12 13141516 17 18192021
28
BRCA1
BLC
28 sporadic BLC
22