1532 / 1983
Calabrese et al., JNCI 2004
Growth of SW620 tumor xenografts after daily
treatment for 5 days with vehicle control alone
(
solid circles, solid bars
),
2 Gy of x-irradiation (IR) vehicle (
solid
squares, shaded bars
),
or 2 Gy of x-irradiation AG14361 at 15 mg/kg
(
open squares, hatched bars
).
PARP inhibitors combined with radiation will also increase the formation of
DSBs and increase cell killing, particularly in a background of reduced levels
of DSB repair proteins.