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More extreme whole breast hypofractionation?

• 115 patients median age 83

• 32.5Gy in 5 x 6.5Gy once-weekly with 6.5Gy boost

• Good local control, grade 3 fibrosis in 6% (95%CI 1.7-9.5)

Centre Antoine-Lacassagne

Courdi

et al

(2006) Radiother Oncol 79:156-161

• 50 patients ≥ 70 years old

• 32.5Gy in 5 x 6.5Gy once-weekly, no boost

• Compared to 317 patients treated 50Gy in 25#

• Equivalent control, no toxicity data

Institut Curie Breast Cancer Study Group

Kirova Y

et al

(2009) Int J Radiat Oncol Biol Phys 75:76-81

• Multicentre randomised trial 2004-2007, 915 patients

• 50Gy 25 # vs. 28.5Gy 5 x 5.7Gy once weekly vs. 30Gy x 6Gy once weekly

• First report at median follow-up 3 years

UK FAST Trial

Fast

Trialists Group (2011) Radiother Oncol 100:93-100