166 / 1983
German Rectal Cancer Study
CAO/ARO/AIO (1995-2002)
•
Study group
–
823 patients
–
Clinical stage T3-4 or N+
(operable)
–
Inferior margin within 16 mm from anal verge
•
Randomisation
–
Chemo-RT (50.4 Gy) + surgery (TME) + 4 x bolus 5-FU
–
Surgery (TME) + chemo-RT (55.8 Gy) + 4 x bolus 5-FU
(Chemo-RT = 5-FU 1000 mg/m2/d D1-5, weeks 1+5)
Sauer R, N Engl J Med. 2004;351(17):1731-40