170 / 1983
Pre-op RT vs selective post-op [C]RT
Study
n
LR p
OS
Uppsala 471 25.5 Gy
13%
0.02
No diff
1980-1985
60 Gy RT 22%
No diff
MRC CR07 1350 25 Gy
4%
<0.0001
No diff
1998-2005
45 Gy CRT 11%
No diff
Dutch TME 1861 25 Gy
6%
<0.001
64%
1996-1999
50.4 Gy RT 11%
63%
Frykholm GJ. Dis Colon Rectum. 1993;36(6):564-72
Sebag-Montefiore D, Lancet. 2009;373(9666):811-20
Peeters KC, Ann Surg. 2007 Nov;246(5):693-701