177 / 1983
Clinical and pathological downstaging
•
83 patients.
Resectable stage II and III
.
•
Randomisation
–
SCRT 25/5 +
delayed surgery
–
LCRT 46 Gy + 5-FU + delayed surgery + 4# chemo
Latkauskas T. Colorectal Dis. 2012;14(3):294-8
SCRT LCRT
p value
Sphincter preservation
70.3%
69.6% 0.342
Post-op complications
40.5% 26.1% 0.221
R0 resection
86.5% 91.3% 0.734
Pathological downstaging 21.6% 39.1% 0.07