556-557 / 1983
Case 1 Chemotherapy
•
Multiple trials demonstrate benefit from adjuvant chemotherapy in
HGG
•
First meta-analysis in 1993
•
16 trials; 3000 patients; 10% improvement in OS
•
12 Trials; IPD MA; 3004 patients; Improved Median OS by 2 months
•
Phase 2 trial of RT + TMZ
Fine, Cancer 1993
Stewart, Lancet 2002
Athanassiou, JCO, 2005
What took you so long ?