562-563 / 1983
Case 1 Chemotherapy
•
No benefit from extended TMZ on OS
•
Multiple retrospective studies show that those who take TMZ for 12 months
live longer than those who take TMZ for 6 months
•
Recent analysis of RCT data suggests maybe PFS improvement but no OS
improvement
•
Why is there is difference between retrospective data and RCT?
•
Is PFS worthwhile?
Blumenthal, NeuroOnc 2017