590-591 / 1983
Case 2
•
NOA-8 study
•
412 pts; GBM or G3 Astrocytoma; >65 yr old; Non-inferiority 25% margin
•
TMZ 100mg/m2 d1-7q14 or
•
RT 60 in 30
•
Median OS 8/12
•
73/209 pts were MGMT-meth
•
MGMT-meth >
MedianOS
MGMT-non-meth (12 vs 8 months)
•
MGMT-meth & TMZ >
EFS
MGMT-meth & RT
•
MGMT-non-meth & RT >
EFS
MGMT-non-meth & TMZ
Wick Lancet Onc 2012