930 / 1983
How to combine…
chemotherapy and RT
Study
Type of
study
n. pts Inclusion
criteria
RT (Gy)
Type of
CT
Main Results
Kumar et al
Phase I 22
IR- HR 70.2
Docetaxel
G2 diarrhea = 36%
G2 dysuria = 23%
Chen et al
Phase I 18
HR
78 (IMRT) Docetaxel
Median FUP 26 mo
bRFS = 94%.
Marchall et al Phase I 19
HR
77.4
Docetaxel
Median FUP 41 mo
bRFS = 80%.
No severe tox.
Sanfilippo et
al
Phase
I- II
22
HR
63-73.8
Dose
escalation
Paclitaxel
Six of the twenty-two
patients experienced a
PSA relapse at a median
follow-up of 38 mo
Perrotti et al
Phase
I-II
20
HR
72 (IMRT) Docetaxel
3 G3 acute tox