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NCT00004054

RTOG-9902: Int J Radiat Oncol Biol Phys. 2015 Oct 1;93(2):294-302

Primary endpoint: 5-year OS

Random

RT 70.2 Gy(RBE)+ ADT 24 m.

RT 79.2 Gy(RBE) + ADT 24 m.

+

paclitaxel, estramustine, and oral

etoposide

No significant differences in OS, biochemical failure, local progression,

distant metastases, or disease-free survival

with the addition of adjuvant CT to LT AS þ RT.