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Clinical evaluation: comparison of toxicity data
from different protocols
•
Biologically Effective Dose
▪
A parameter that is independent from the fractionation
▪
It doesn’t express a real delivered dose
/
/
2
1
1
2
+
+
=
d
d
D
D
1
/
0
/
1
1
+
+
=
d
D
BED
2
+
=
+
=
1
/
1
/
1
1
1
1
d
dN
d
D BED
3
N
: fraction number
d
1
: fraction number
/
: alfa-beta ratio
for the given effect