Course book Advanced Treatment Planning 2018

259 / 1161

Parameters for clinical outcome: Brain
Radiation necrosis (%)
0
5
10
15
20
25
30
0
5
10
15
20
25
30
35
40
45
50
0 25 50 75 100 125 150 175 200
0
5
10
15
20
25
30
0 25 50 75 100 125 150 175 200
0 25 50 75 100 125 150 175 200
BED (Gy)
n<60
n=160-120
n>120
n<60
n=160-120
n>120
n<60
n=160-120
n>120
d1 < 2.5 Gy d1 ≥ 2.5 Gy
Twice daily
fraction
Lawrence YR et al. Radiation Dose-Volume
effects in the brain. Int. J. Radiation Oncology
Biol. Phys., Vol. 76, No. 3, Supplement, pp.
S20–S27, 2010.