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Multivariate NTCP model:

use of logistic regression for fitting different covariates (in addition to dose):

Parameters for clinical outcome: Salivary glands

Beetz I et al. Development of NTCP models for head and neck cancer patients treated with

three-dimensional conformal radiotherapy for xerostomia and sticky saliva: The role of

dosimetric and clinical factors. Radiother. Oncol. Volume 105, Issue 1, Pages 86–93.

X

e

NTCP

ˆ

1

1

+

=

nn

x

x x

X

+ + +

+ =

22

11

0

ˆ

NTCP

X

ˆ