1122 / 1416
OER
and
RBE
derived from clonogenic survival after irradiation in different oxygen
atmospheres with X Rays or 12C ions in the plateau or in the Bragg Peak
Dose [Gy]
hypoxic conditions
S
p
e
ci
fi
c
g
r
o
w
t
h
d
e
l
a
y
[
Staab et al. 2004
LET
(keV/µm)
X rays ~ 2
2.87
* 1.00*
1.00
12C (plateau) 18
2.76
* 1.39*
1.45
12C (Bragg peak) 60
1.40
** 2.11**
4.31
OER
RBE
Aerobic Hypoxic***
* calculated for an aerobic pO2 = 145 mmHg
** calculated using an aerobic pO2 = 690 mmHg
*** pO2 = 0 mmHg
Par$cles: effect on hypoxic cells
(Carbon Ions)