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Particles: unique cellular & tissue effects
p21
(cyclin-dependent kinase inhibitor)
= cell cycle arrest
(Scholz 2001 Rad. Res.)
more pronounced and
accelerated reoxygena1on
more damage to oxygen
deficient cells
(hypoxic cells)
higher efficacy against quiescent
endothelial cells
(vasculature)
cellular & tissue level
higher efficacy against low
prolifera1ng/quiescent stem cells