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Why studying tumor response ?
increased radioresistance
due to inherent or aquired
gene-c
altera-ons
(mut. tumor suppressors,
cell death disregula6on, etc)
EG
F
GT
V
Endotheliu
m
P
Tumor
VEGF
R
VEG
F
a
v
b
3
PI3
K
AK
T
Apoptosi
s
PDGF
R
P
P
P
PDGF
R
PDG
F
P
EG
F
prostatic adenocarcinoma
Shain & Dalton 2001
Cordes et al. 2002
Abdollahi et al. 2003
due to
structural
and
func-onal
tumor characteris6c (e.g. hypoxia,
acidosis, growth and differen6a6on
status, number of clonogens)
lower radia-on response
due to radia6on-induced upregul-
a6on of
protec-ve processes
(e.g.
cellular stress response, angiogenic
pathways)
x-ray-induced resistance