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Plateau

(13 keV/µm)

Set-up Photons Carbon Ions Measured Calculated *

D50 [Gy] D50 [Gy] RBE RBE

1 Fx

24.5

±0.8

17.1

±0.8

1.43

±0.08

1.14

(1.12-1.16)

2 Fx

34.2

±0.7

24.9

±0.7

1.37

±0.05

1.19

(1.17-1.21)

6 Fx

57.0

±4.0

42.8

±1.5

1.33

±0.10

1.37

(1.35-1.39)

18 Fx 88.6

±2.0

62.2

±3.5

1.42

±0.09

1.72

(1.65-1.77)

Peak

(91 keV/µm)

1 Fx

24.5

±0.8

13.9

±0.8

1.76

±0.12

1.28

(1.26-1.30)

2 Fx

34.2

±0.7

15.8

±0.7

2.16

±0.11

1.61

(1.57-1.65)

6 Fx

57.0

±4.0

19.2

±0.2

2.97

±0.21

2.35

(1.25-2.44)

18 Fx 88.6

±2.0

17.7

±1.3

5.01

±0.37

3.80

(3.50-4.20)

Results

Effec%ve response in

the

Bragg-Peak

,

with

li3le change in

isoeffec%ve total dose

with frac%ona%on

RBE raises

rapidly

with decreasing dose

per frac%on