1136 / 1416
op#c nerves
spinal cord
paro#s
12Carbon
Ions
normal (ssue proximal to PTV
Correla#on of LET and RBE
not
linear across complete range
; RBE
of normal #ssues o9en not known
a non-negligible volume of
normal
(ssue
surrounding the tumor might
be included
in the (high-LET)
volume
max. LET o=en close to PTV
PTV
= planning target volume
GTV
normal (ssue in the GTV
(a) tumors can be
intertwined
in a
substrate of normal #ssue
(b) tumors
contain
normal #ssue
structures
(stroma, vasculature etc.)
Why studying normal tissue response ?