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Abbott Nutrition Division

Simultaneous Determination of Total Vitamin B

6,

B

2,

B

3

and B

1

in

Infant Formula Products by LC-MS/MS Using Enzymatic Digestion

A.

SAFETY

LABORATORY CHEMICALS SHOULD BE HANDLED WITH THE PRECAUTIONS, CARE

AND RESPECT THAT ALL POTENTIALLY HAZARDOUS MATERIALS REQUIRE. AVOID

SKIN CONTACT AND INJESTION OF ALL COMPOUNDS, REAGENTS AND SOLUTIONS

USED IN THIS PROCEDURE.

MOST REAGENTS USED IN THIS METHOD POSE MINIMAL HEALTH AND/OR FIRE

HAZARDS. THOROUGHLY FLUSH ANY AREA COMING IN CONTACT WITH ANY

REAGENTS USED IN THIS METHOD WITH WATER.

IN GENERAL, DILUTE SOLUTIONS PRODUCED TO SUPPORT THE PREPARATION OF

SAMPLES FOR ANALYSIS, MOBILE PHASE COMPONENTS AND SAMPLE EXCESS

SAMPLE EXTRACT VOLUMES CAN BE DISCARDED DOWN THE DRAIN. WASTES

GENERATED SHOULD BE DISCARDED IN ACCORD WITH ALL CORPORATE, LOCAL

AND FEDERAL REGULATIONS.

THROUGHOUT THIS DOCUMENT STEPS REQUIRING SPECIFIC SAFETY PRECAUTIONS

OR PERSONAL PROTECTIVE EQUIPMENT ARE DENOTED BY THE FOLLOWING

SYMBOLS:

USE OF GLOVES IS REQUIRED. LATEX, NITRILE OR RUBBER GLOVES ARE

RECOMMENDED.

PERFORM THIS PROCEDURAL STEP USING A WORKING FUME HOOD. THE

CHEMICALS USED IN THIS STEP REPRESENT AN INHALATION HAZARD.

1.

METHANOL

TOXIC!

CAN CAUSE BLINDNESS. CUMULATIVE POISON. HARMFUL IF

INHALED, SWALLOWED, OR ABSORBED THROUGH SKIN. USE WITH ADEQUATE

VENTILATION AND AVOID BREATHING VAPORS. AVOID CONTACT WITH SKIN OR

EYES.

19

BVit-02

FOR ERP USE ONLY

DO NOT DISTRIBUTE