PowerPoint Presentation

Uncertainties related to

1.Source calibration

2.a) Dose calculation in water

b) Systematic effects in the clinical setting

3.Accuracy of afterloader performance

(time/spatial distribution)

4.Imaging (reconstruction, volume interpolation,…)

5.Contouring

6.Variations at patient level (inter- and intrafraction variations,

organ movement/swelling)

Mainly site specific

~ 1,5 %

~ 4 %

up to 10 %

~ 2 %

~ 5 %

x %

~10 %**

up to ~50%

Order of magnitude for target dose - HDR BT

“10% Expert level”

C Kirisits et. al 2013