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A Phase II Randomized Trial Comparing Intensity Modulated Radiation Therapy
(IMRT) with Conventional Radiation Therapy in Stage IIB Carcinoma Cervix
(NCT00193804/TMH/158/2004):
November 2004
Carcinoma Cervix Stage IIB (SQ / Adeno CA)
100 patients
Conventional External RT (40 Gy /20#)
+ ICA – HDR (7 Gy x 5#)
with Concomitant Chemo-radiation
100 patients
IMRT Pelvis (50 Gy/25#)
+ ICA – HDR (7 Gy x 5#)
with Concomitant Chemo-radiation
• Reduction in Acute and Late RT toxicity’s by:15-25%
• Accrual Period: 5 years
• Power of detection: 80% (alpha error: 0.05)
Final Analyses: October 2016
HYPOTHESIS: