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Clinical radiobiology
All models are wrong, but some are useful
(David R. Wigg)
LQ-model has proven to be a useful tool for radiobiological calculations in
brachytherapy:
Fowler JF. Dose reduction factors when increasing dose rate in LDR or MDR brachytherapy of carcinoma of the
cervix.
Radiother Oncol 1997;45:49-54.
Dale RG et al. Calculation of integrated biological response in brachytherapy. Int J Radiat Oncol Biol Phys
1997;38:633-642.
Nag S, et al. A simple method of obtaining equivalent doses for use in HDR brachytherapy. Int J Radiat Oncol
Biol Phys
2000;46:507-513.
Lang S, et al. Treatment planning for MRI assisted brachytherapy of gynecologic malignancies based on total
dose constraints. Int J Radiat Oncol Biol Phys 2007;69:619-627
The effect of alternative biological modelling parameters (a/b and half time of repair T1/2) on reported EQD2
values in the treatment of advanced cervical cancer. De Leeuw 2011 Radiother Oncol Nov 101(2) 337-42
Determining DVH parameters for combined external beam and brachytherapy treatment: 3D biological dose
adding for patients with cervical cancer Van de Kamer 2010, RaditherOncol 94;248-253
Despite all limitations and simplifications, the LQ-model can be used
for treatment planning and reporting