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Effect of uncertainties on observed
dose response relationships
Comparison of model dose response curve (based on published curves, see previous slides), and simulated
„observed“ dose response curves assuming different systematic and random uncertainties.
systematic
dosimetric uncertainty
e.g. rectum D
2cm³
(+3,+5,+10,+15 % / fx)
random
dosimetric uncertainty
e.g. rectum D
2cm³
(±10, ±20, ±30 % / fx)
Simulations of patient cohort with total dose = 45Gy EBRT + 4 fx BT (equal PD for each fx), model based on
Georg er al. 2012, IJROBP
“Can reduction of uncertainties in cervix cancer brachytherapy potentially
improve clinical outcome?” Nesvacil et al. 2016, submitted to R&O
Courtesy Nicole Nesvacil, MUW