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PEPaNIC trial

141

7

SUPPLEMENTARY FIGURES

Total

No. in PICU

Late PN

Early PN 723

399

216

139

93

717

348

159

103

63

723

399

216

139

93

717

348

159

103

63

723

399

216

139

93

717

348

159

103

63

Total Energy

(kcal/kg/day)

Enteral

Parenteral

Early PN

Late PN

0

25

50

75

100

0

25

50

75

100

d1

d4

d8

d12

d16

d1

d4

d8

d12

d16

Carbohydrates

(gram/kg/day)

2.5

5

7.5

10

12.5

0

d1

d4

d8

d12

d16

2.5

5

7.5

10

12.5

0

2.5

5

7.5

10

12.5

0

d1

d4

d8

d12

d16

d1

d4

d8

d12

d16

2.5

2.5

Protein

(gram/kg/day)

d1

d4

d8

d12

d16

0

0.5

1

1.5

2

0

0.5

1

1.5

2

2.5

d1

d4

d8

d12

d16

0

0.5

1

1.5

2

d1

d4

d8

d12

d16

Fat

(gram/kg/day)

Day after Inclusion

Day after Inclusion

Day after Inclusion

d1

d4

d8

d12

d16

0

0.5

1

1.5

2

2.5

3

3.5

0

0.5

1

1.5

2

2.5

3

3.5

d1

d4

d8

d12

d16

0

0.5

1

1.5

2

2.5

3

3.5

d1

d4

d8

d12

d16

0

25

50

75

100

d1

d4

d8

d12

d16

Supplementary Figure 1.

Caloric and macronutrient intake per kg

Daily amount of energy in kcal/kg/day, and the daily amounts of substrates in g/kg/day, for the first 16

days of pediatric intensive care unit (PICU) stay provided by the enteral route, the parenteral route or both

(total). Bars represent the mean and the whiskers represent the standard error of the mean (SEM). The red

bars represent the late parenteral nutrition (PN) group; the blue bars represent the early PN group.