Proefschrift Kerklaan

Chapter 7

144

SUPPLEMENTARY TABLES

Supplementary Table 1.

Exclusion criteria for study participation

Not critically ill enough to necessitate nutritional support

STRONGkids score lower than 2 on PICU admission

Non-pediatric patients (aged 17 or older)

Premature newborns (<37 weeks gestational age upon admission in the PICU)

‘Do not resuscitate’ code at the time of PICU admission

Expected death within 12 hours

Readmission to PICU after already having been randomized

Enrollment in another intervention trial

Transfer from another PICU or neonatal ICU after a stay of more than 7 days

Ketoacidotic or hyperosmolar coma

Inborn metabolic diseases requiring specific diet

Short bowel syndrome or other conditions requiring PN for more than 7 days prior to PICU admission

PICU=Pediatric Intensive Care Unit, PN=Parenteral Nutrition

Supplementary Table 2.

Local protocols for initiation of PN in early PN group, in all participating centers EN

was attempted as soon as possible

Center

On admission

Day 2

Day 3

Subsequent Stay

Leuven,

Belgium

Mixture of glucose

30% and Vaminolact®

(Fresenius)

Addition of lipids

(SMOFlipid®

Fresenius)

All replaced by

mixture of glucose

50% and SMOFlipid®

with Vaminolact® or

Vamin 18®.

Glucose 50% and

SMOFlipid® with

Vaminolact® or Vamin

18®

Rotterdam,

The Nether-

lands

Continuous glucose

infusion with glucose

intake 4-6 mg/kg/

min (< 30 kg) or 2-4

mg/kg/min (> 30 kg)

Pharmacy-made PN:

mixture of glucose,

Primene® (Baxter)

and Intralipid®

(Fresenius, 50% of

final dose). Children

>30 kg Olimel®

(Baxter, N5 or N4

depending on central

or peripheral line)

Increase of lipids to

100%

Pharmacy-made PN:

mixture of glucose,

Primene® (Baxter)

and Intralipid®

(Baxter, 100% of final

dose). Children >30

kg Olimel® (Baxter,

N5 or N4 depending

on central or

peripheral line)

Edmonton,

Canada

Continuous glucose

infusion with glucose

intake 3-4 mg/kg/

min

Addition of 20% IV

lipids (50% of final

dose)

Increase of lipids to

100%

Mixture amino acids

and concentrated

glucose

Mixture amino acids,

concentrated glucose

and 20% IV lipids

EN=Enteral Nutrition, IV=Intravenous, PN=Parenteral Nutrition