150 / 208
Chapter 7
148
Supplementary Table 8.
Highest plasma concentrations during PICU stay for markers of liver dysfunction and
inflammation. Mean plasma glucose concentration during PICU stay
Early PN Late PN P-value
Highest plasma concentration during PICU stay
N=723
N=717
Liver dysfunction - mean (SEM)
Highest plasma bilirubin – mg/dL (N = 1261)
1.6 (0.1)
1.9 (0.2)
0.006
Highest plasma Alkaline Phosphatase (N=1236)
195 (5)
182 (6)
0.001
Highest plasma GGT – IU/L (N = 1225)
85 (7)
64 (5)
0.003
Highest plasma ALT – IU/L (N = 1270)
85 (9)
118 (20)
0.33
Highest plasma AST – IU/L (N = 1268)
202 (28)
271 (48)
0.82
Inflammation - mean (SEM)
Highest plasma CRP – mg/L (N = 1307)
87 (4)
93 (4)
0.09
Mean plasma glucose – mg/dL (N= 1391)
117 (1.5)
100 (1.2)
< 0.001
PN=Parenteral Nutrition, PICU=Pediatric Intensive Care Unit, SEM= Standard Error of the Mean, GGT=
Gamma-Glutamyltransferase, ALT= Alanine Aminotransferase, AST= Aspartate Aminotransferase, CRP=
C-reactive protein