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Table 1.
Overview of 5 RCTs and 1 post-hoc analysis identified as support of use of parenteral nutrition (PN) in critical ill children
Study
Patients
Comparator
Intervention
Outcome parameters
Limitations
Jordan I. et al. Clin Nutr. 2015
Glutamine effects on heat shock
protein 70 and interleukines 6 and
10: Randomized trial of glutamine
supplementation versus standard
parenteral nutrition in critically ill
children
13
101 patients (1 month
-14 years) with severe
sepsis or post major
surgery
Standard PN (SPN)
Standard PN plus Glutamine
0.33g/kg/d (SPN + Gln)
High Heat Shock Protein-70
longer maintained in SPN
+ Gln. No difference in
interleukin 6, interleukin 10
1) Surrogate endpoints
Larsen B. et al. JPEN J Parenteral
Enteral Nutr. 2015;39:171-179
Pretreatment with an intravenous
lipid emulsion increases plasma
eicosapentanoic acid and
downregulates leukotriene b4,
procalcitonin, and lymphocyte
concentrations after open heart
surgery in infants
11
32 patients (neonates
40 weeks ± 2.2 weeks)
post cardiac surgery
Standard group
Intralipid®
Intervention group
Lipoplus® (50% MCT, 40%
LCT, 10% Fish oil)
Intervention group:
Procalcitonin lower in at day 1,
Leukotriene B4 higher at day
1 and 7, but lower at day 10.
Lymphocyte concentration
lower
1) Post-hoc analysis
2) Underpowered to draw
clinical conclusions
3) Intervention already started
before surgery
Lekmanov A. et al.Anesteziol
Reanimatol 2013;
Jan-Feb;(1):49-51
Study of glutamine solution use
efficiency in pediatric patients
with heavy thermic burns and
concomitant injuries in the
intensive care unit
14
40 patients
(2-15 years old) with
thermic burns
Standard PN
Standard PN plus glutamine
(2 ml/kg)
Intervention group: shorter
duration of mechanical
ventilation. No differences in
levels of protein, albumin or
glutamine
1) No statistical analysis
description
2) Methods inaccurately
described
3) Glutamine levels not
different between groups
Larsen B. et al. Clin Nutr. 2012
Jun;31(3):322-9
Pre-treatment
with an intravenous lipid
emulsion containing fish
oil (eicosapentaenoic and
docosahexaenoic acid) decreases
inflammatory markers after
open-heart surgery in infants: a
randomized, controlled trial
17
32 patients (neonates
40 weeks ± 2.2 weeks)
post cardiac surgery
Standard group Intralipid® Intervention group
Lipoplus® (50% MCT, 40%
LCT, 10% Fish oil)
Intervention group: TNF alpha
plasma levels lower prior
to and after surgery. Pro-
inflammatory markers lower
1) Surrogate endpoints
2) No clinical outcome
difference
3) Intervention already started
before surgery