95 / 208
Evidence for the use of PN in the PICU
93
5
Chaloupecky, V. et al. J Thorac
Cardio-vasc Surg 1997;114:1053-60
Nitrogen balance,
3-methylhistidine excretion, and
plasma amino acid profile in
infants after cardiac operations for
congenital heart defects: the effect
of early nutritional support
10
37 patients (2 months
-1 year) post cardiac
surgery
Standard group
Glucose 10%
25 kcal/kg
Intervention only on day 1
postoperatively afterwards
EN (no PN)
PN group
Glucose 10-20% and amino
acid 0.8 g/kg/d
33 kcal/kg
Intervention only on day 1
postoperatively afterwards EN
(no PN)
PN group: Nitrogen balance
less negative on day 1.
Standard group: decrease
in plasma levels of branched
amino acids (valine, leucine,
isoleucine), alanine, glycine
and proline on day 2
1) Surrogate endpoints
2) Short intervention time
Chaloupecky, V. et al. Cor et Vasa
1994;36:26-34
The effect of early
parenteral nutrition on amino
acid and protein metabolism in
infants following congenital heart
disease surgery in extracorporeal
circulation
12
29 patients
(6.5 months ± 3
months) post cardiac
surgery
Standard group Glucose
10%
Intervention only on day 1
postoperatively afterwards
EN (no PN)
PN group Glucose 20%
and amino acid 0.8 g/kg/d
Intervention only on day 1
postoperatively afterwards EN
(no PN)
PN group: Nitrogen balance
less negative on day 1.
Standard group: decrease
in plasma levels of branched
amino acids (valine, leucine,
isoleucine), glutamine,
arginine and proline on day 2
1) Surrogate endpoints
2) Short intervention time