561 / 1835
NFT
PET/CT
Deauville
Score 1,2, 3
stratfiy according to
residual mass
> 2.5 cm
BULK-ISRT
30 Gy
CD20
+
DLBCL
Bulk
(
≥
7.5cm
any dimension
)
>16 years
Outline of trial design in DLBCL
PET/CT
Deauville
Score 4,5
6 xRCHOP
Local practice
Central PET review
RT QA
End point: PFS
Assuming PFS at 1,2 & 6ys
of 80%, 75% and 73% in the
NFT arm and 88%, 85%
and 83% in RT arm
(HR=0.565):
Sample size: 480 (5ys)
PET