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Somatic mutations in cancer
Majority of coding sequence of 11 colorectal tumors:
Total # mutated genes in
11
tumors:
769
Average # somatic protein coding mutations in
1
tumor:
77
Estimated # driving mutations in
1
tumor:
10
Minimal overlap in mutation spectrum between tumors.
Large number of
“
passenger
”
mutations. These do not contribute
to tumorgenesis, co-selection of random events with
the
“
driving
”
mutations.
From Wood et al., Science 2007