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Withers 1966: Skin remains intact if clonogen survival is higher
than about 5 per 10
-6
per cm
2
. Higher doses will cause moist
desquamation.
Dose-response for skin epithelium
20 days after 15Gy
Dose-survival curves for mouse skin
epithelial clonogenic (stem) cells in
conditions of hyperbaric oxygen, air
breathing or ischemic hypoxia induced
by compression.
hypoxia
air
oxygen
Two clonally-derived islands of epithelium
in a 1 cm diameter radiation-induced ulcer
of the skin on the back of a mouse. Rapid
regrowth on epithelial surfaces such as
skin and mucosa provide a reason for
protracting radiation therapy over several
weeks.