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Withers 1966: Skin remains intact if clonogen survival is higher

than about 5 per 10

-6

per cm

2

. Higher doses will cause moist

desquamation.

Dose-response for skin epithelium

20 days after 15Gy

Dose-survival curves for mouse skin

epithelial clonogenic (stem) cells in

conditions of hyperbaric oxygen, air

breathing or ischemic hypoxia induced

by compression.

hypoxia

air

oxygen

Two clonally-derived islands of epithelium

in a 1 cm diameter radiation-induced ulcer

of the skin on the back of a mouse. Rapid

regrowth on epithelial surfaces such as

skin and mucosa provide a reason for

protracting radiation therapy over several

weeks.