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Segment of mouse intestine irradiated with varying doses
XRT
12.5Gy
14.0Gy
15.5Gy
17.0Gy
a
b
c d
Day 13
Overt tissue response (e.g. ulceration) is dose-dependent with a threshold followed by a
rapid increase in severity.
a. Patchy breakdown of mucosa except in shielded mucosa at top of specimen.
b. Ulcerated mucosa being resurfaced by near-confluent nodules regenerated from a
large number of independently surviving jejunal clonogens.
c. Severe ulceration but with about 60 discrete clonogen-derived mucosal nodules.
d. As for c. but only 4 regenerated nodules.