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Small bowel toxicity
•
Acute toxicity
•
Results of cell death in
proliferative compartment
•
Failure to replace the villus
epithelium
•
Shortening of the villus
•
Endothelial cell swelling and
loss with increased vascular
permeability
•
Breakdown of the mucosal
barrier
•
Mucositis
Consequential late effects
Dörr, Radiother Oncol 2001
Impairment
of barrier
function