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1/03/2016
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Relevant factors
•
Patient
-related factors influencing normal tissue
reactions
•
Age
•
Co-morbidity (e.g. cardiovascular diseases, diabetes)
•
Genetic syndromes (e.g. Ataxia Telangiectasia)
•
Infection (e.g. IBD, Crohn’s disease)
•
Interaction with other treatments (e.g. chemotherapy)
•
Patient’s general condition
•
Smoking
23
Tumor-related factors
•
Stage of disease
•
Volume of the tumor
•
Lymphatic spread
•
Radiation dose
•
Volume of normal tissue irradiated
•
Fractionation schedule
•
Use of concomitant chemotherapy