00_MJ_Intro_Budapest16.pptx

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1/03/2016

18

Relevant radiobiological factors

•

Fractionation schedule: relation to EQD

2Gy

35

Yarnold Radiother Oncol 2005

α/β = 3

EQD

2Gy

39Gy/13fx

46.8Gy

50Gy/25fx

50Gy

42.9Gy/13fx 54Gy

Alpha/beta value of 3.6 Gy

(95% CI 1.8-5.4 Gy)

Relevant radiobiological factors

•

Fractionation schedule

36

Haviland Lancet Oncol 2013

Hypofractionated

radiotherapy is safe and

effective for patients with

early breast cancer