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Relevant factors
•
Radiobiological
-related factors influencing normal
tissue reactions
•
Intrinsic radiosensitivity (L2.3)
•
Total radiation dose (L3.5)
•
Technique and irradiated volume (L3.6)
•
Fractionation schedule (late reactions) (L2.3)
•
Overall treatment time (early reactions) (L2.4)
•
Concomitant treatment (L4.4, L5.2)
25
Relevant radiobiological factors
•
Intrinsic radiosensitivity
26
Alsner J Radiother Oncol 2007 26 pts
Sensitive profile
Resistant profile
Differential gene expression in irradiated fibroblasts between pts
with variable risk of radiation-induced fibrosis
26 patients derived fibroblasts
Hierarchical clustering
3 x 3.5 Gy