269 / 1173
1/03/2016
21
How to measure normal tissue response?
•
Scoring of gross tissue effects
•
Scoring systems: grade the severity of tissue damage
using an arbitrary scale
•
Assays of tissue function
•
Functional assays to measure radiation effects
•
E.g. blood counts as an indicator of bone marrow function
•
Clonogenic assays (L1.4)
•
Methods by which colony of cells that derive from a
single irradiated cell can be observed
41
Scoring of side-effects: frequency
•
Two aspects must be considered for documentation
•
Frequency
•
Early reactions can undergo considerable changes in clinical
manifestation in short periods
•
Scoring at weekly basis: during and for some weeks after RT
•
Late reactions develop slowly and are usually irreversible
•
Scoring at intervals of several months after the end of RT (dynamics)
•
At later time points at annual intervals
42